The gender aspects of traditional knowledge (TK) protection highlight the important link between intellectual property rights, TK, women and sustainable development. Indigenous and local women’s TK is not only distinct and relevant, but also crucial for accomplishing the United Nations Sustainable Development Goals. National governments and international organizations dealing with TK should pay attention to gender aspects of the issue. Policies and initiatives that ignore gender aspects of TK can have serious implications for the survival and development of Indigenous and local communities and TK itself as a dynamic and living body of knowledge. The economic significance of TK and its trade value make it an enabler of sustainable development and women’s economic empowerment, especially in light of the World Trade Organization’s recent Declaration on Trade and Women’s Economic Empowerment.